NanoBone®

Bone reconstruction in a new dimension

The ^NanoBone® synthetic material offers dentists a safe material for bone reconstruction. In over 5 years of use in dental practices, with over 100,000 treatments worldwide, ^NanoBone® has proven its worth. Users have access to a variety of products for specific indications. The ^NanoBone® synthetic reconstruction material is available in granular or block form. A comprehensive technology – ^NanoBone® technology – offers a wide range of products that simplify daily work in the dental practice. Long-term studies confirm all the good reasons for choosing ^NanoBone® .

Benefits of NanoBone®

• Very rapid bone formation
• Complete remodeling
• Efficient, thanks to its nanostructure
• Synthetic and safe

NanoBone® Granular

For daily surgical use, ^NanoBone® in granular form is available in very small granules (0.6 x 2 mm) or small granules (1 x 2 mm), depending on the indication and the size of the defect. To address various indications with specific products, ^NanoBone® technology offers granules with differentiated resorption kinetics. ^NanoBone® in granular form was the first product of ^NanoBone® technology and was launched on the market in 2005. Those who use it swear by its ease of use. By mixing it with the patient's blood, a paste-like consistency is obtained that can be easily inserted, with appropriate instruments, wherever needed.

NanoBone®, product features

Not sintered

All ^NanoBone® technology products are produced using the sol-gel process at 700°C. This low temperature prevents the material from sintering, resulting in a highly porous surface with pores ranging from nanometers to micrometers in size. Autologous blood proteins penetrate these nanopores, covering their entire internal surface. Our body recognizes ^NanoBone® as an endogenous element, triggering the natural remodeling process.


Osteoconduction

Harms et al. attribute ^NanoBone® to a high osteoconductive potential. The augmentation material acts as a guardrail. The formation of a protein-rich organic matrix promotes the ingrowth of connective tissue and blood vessels.

Osteoinduction

Götz et al. demonstrated the osteoinductive nature of ^NanoBone® . Attraction and differentiation of osteoblasts and osteoclasts could be demonstrated. In animal experiments with Göttingen minipigs, ectopic bone formation was observed.

What is NanoBone®?

In addition to bone replacement materials previously available on the market, ^NanoBone® technology represents a completely new group. Nanocrystalline hydroxyapatite (HA) is embedded in a silica gel ( _SiO2 ). This nanocrystalline hydroxyapatite approximately corresponds to that found in autologous bone. The silica gel promotes collagen and bone formation.

Nanotechnologies

Produced using the sol-gel process at temperatures up to 700°C, the material is not sintered and features pores ranging from nanometers to micrometers in size. The potential of nanotechnology is exploited with HA nanocrystals and interconnecting nanopores. Blood proteins cover the entire internal surface (approximately 84 m²/g), and the body recognizes the biomaterial almost as if it were an endogenous element.

The change of matrix

Within the first two weeks, the silica gel matrix transforms into an organic matrix. Through this process, each ^NanoBone® granule now corresponds to the extracellular matrix of bone tissue.

Remodeling

^NanoBone® promotes natural remodeling. The attraction and differentiation of osteoblasts and osteoclasts strongly suggest the biomaterial's osteoinductive nature.

NanoBone® Technology

What does NanoBone® Technology mean?

1. Autologous blood proteins enter the nanopores of the granules, covering their entire surface (>80 m²/g). The body recognizes ^NanoBone® as an endogenous element.
2. The hairy structure allows for rapid capillary growth. This process is facilitated by changes in the matrix.
3. ^NanoBone® is completely replaced by bone during this process. With volume stabilization, ^NanoBone® is resorbed to the extent that new autologous bone is formed. * Meier et al
4. Within a few days, the silica gel matrix is ​​replaced by an organic matrix containing important proteins for osteogenesis (BMPs, osteocalcin, osteopontin).* Götz et al.
5. Osteoclasts resorb the ^NanoBone® granules as bone. At the same time, osteoblasts form new natural bone. This resorption of the augmentation material and the formation of new autologous bone occur in the same way as natural bone remodeling.