Nanobone Granular 2.4ml Artoss

NanoBone® Granular 2.4 ml Artoss is a synthetic material for bone reconstruction in dentistry, consisting of nanocrystalline hydroxyapatite incorporated in a silica gel.

Product format

• Presentation: granular material max 1mm.
• Volume: 2.4 ml.

NanoBone® for bone reconstruction

Bone reconstruction in a new dimension

With the synthetic material NanoBone^® the dentist is offered a safe material for bone reconstructions. After more than 5 years of use in office settings with over 100,000 treatments worldwide, NanoBone^® has proven all its qualities. Users can choose from a variety of products for specific indications. The NanoBone^® synthetic reconstruction material is available in granular or block form. An entire technology – the NanoBone^® technology – offers a wide range of products, which simplify daily work in the dental office. Long-term studies confirm all the good reasons to choose NanoBone^®.

Advantages of NanoBone®

• Very rapid bone formation
• Complete remodeling
• Efficient, thanks to its nanostructure
• Synthetic and safe

NanoBone® Granular

NanoBone^® in granular form is available, for daily surgical use, according to the indication and the size of the defect, in very small granules (0.6 x 2 mm) or small granules (1 x 2 mm). In order to treat the various indications with specific products, the NanoBone^® technology makes available granules with differentiated resorption kinetics. NanoBone^® in granular form is the first product of the NanoBone^® technology and was launched on the market in 2005. The product description highlights its ease of use. By mixing it with the patient's blood, a paste-like consistency is obtained that can be easily inserted, with appropriate instruments, where needed. 

NanoBone®, product features

Un-sintered material

All products of the NanoBone^® technology are produced using the sol-gel method at 700° C. Thanks to this low temperature, the material is not sintered, presenting a highly porous surface with pores ranging from nanometers to micrometers. The autologous blood proteins penetrate into these nanopores, coating their entire inner surface. Our body recognizes NanoBone^® as an endogenous element and this triggers the natural remodeling process.

Osteoconduction

Harms et al. attribute a high osteoconductive potential to NanoBone^®. The augmentation material acts as a guardrail. With the formation of a protein-rich organic matrix, the internal growth of connective tissue and blood vessels is promoted.

Osteoinduction

Götz et al. have demonstrated the osteoinductive nature of NanoBone^®. It could be demonstrated an attraction and differentiation of osteoblasts and osteoclasts. In animal experiments with Gottinga piglet, ectopic bone formation was observed.

What is NanoBone®?

In addition to the bone replacement materials previously available on the market, the NanoBone^® technology represents a completely new group. Nanocrystalline hydroxyapatite (HA) is incorporated in a silica gel (SiO₂). This nanocrystalline hydroxyapatite corresponds approximately to that present in autologous bone. The silica gel promotes the formation of collagen and bone. 

Nanotechnologies

With production according to the sol-gel method at temperatures up to 700° C, the material is not sintered and presents pores ranging from nanometers to micrometers. The potential of nanotechnology is exploited with HA nanocrystals and interconnected nanopores. The blood proteins coat the entire inner surface (ca. 84 m²/g) and the body recognizes the biomaterial almost as an endogenous element. 

The matrix change

Within the first two weeks, the silica gel matrix transforms into an organic matrix. Through this process, every granule of NanoBone^® now corresponds to the extracellular matrix of bone tissue.

Remodeling

NanoBone^® promotes natural remodeling. The attraction and differentiation of osteoblasts and osteoclasts strongly suggest an osteoinductive biomaterial character.

The NanoBone® technology

What does NanoBone® Technology mean?

1. Autologous blood proteins enter the nanopores of the granules, coating their entire surface (> 80 m²/g). The body recognizes NanoBone^® as an endogenous element.
2. The woolly structure allows the rapid growth of capillaries. This process is facilitated by the matrix change.
3. NanoBone^® is completely replaced by bone during this process. With the stabilization of the volume, NanoBone^® is resorbed to the extent that new autologous bone is formed. * Meier et al
4. Within a few days, the silica gel matrix is replaced by an organic matrix containing important proteins for osteogenesis (BMP, osteocalcin, osteopontin).* Götz et al.
5. Osteoclasts resorb NanoBone^® granules like bone. At the same time, osteoblasts form new natural bone. This resorption of the bone augmentation material and the formation of new autologous bone occur in the same way as natural bone remodeling.